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Chronic Fatigue Syndrome

What is it?

Chronic fatigue syndrome (CFS) is a condition whose main symptom is extreme fatigue that lasts for six months or longer, in combination with symptoms ranging from joint pain to loss of concentration. Syndromes are illnesses that consists of a group of symptoms that occur together but don’t necessarily have the same cause. CFS may also be called myalgic encephalomyelitis, post-viral fatigue syndrome, Epstein-Barr disease, or chronic fatigue and immune dysfunction syndrome (CFIDS). Because it tends to occur in middle-income young adults, it has also been called the Yuppie flu.

Who gets it?

CSF is diagnosed more often in women than in men, possibly because women are more likely than men to discuss their symptoms with a doctor. However, this condition has been reported in people of all ages, races, and socioeconomic classes. Most people diagnosed with CFS are in the 20 to 40 age range.

What causes it?

Doctors have been unable to find one single cause of CSF. Many patients with CSF have high levels of antibodies to the Epstein-Barr virus, as well as other viruses, in their blood. Epstein-Barr causes mononucleosis. However, many healthy people also have high levels of Epstein-Barr antibodies. So, it is possible, but not conclusive, that a virus or group of viruses may trigger CFS. Other possible causes include allergies, chemical toxins, anemia (low iron levels), hypoglycemia (low blood sugar), high stress levels, or immune disorders. While living with the symptoms of CSF may cause depression, most researchers do not believe that it is caused by a psychological disorder.

What are the symptoms?

People with CSF experience fatigue so severe that they are unable to carry out normal day-to-day activities. This fatigue may be constant, or may come and go. Other symptoms can include joint and muscle pain; swollen, painful lymph nodes; low-grade fever; sore throat; headache; persistent fatigue even after a full-night’s sleep; extreme fatigue after exercise; inability to concentrate; and short-term memory loss. Studies have shown that some patients have an abnormality in blood pressure regulation, causing light-headedness and fainting.

How is it diagnosed?

To diagnose CFS, your doctor will take a complete medical history and perform a thorough physical examination. He or she will also perform a neurological examination and order laboratory tests to rule out other possible causes of your symptoms. CSF is diagnosed only when any other causes can be ruled out and symptoms of unexplained, severe fatigue have occurred for six months or longer in combination with at least four of the other typical CSF symptoms.

What is the treatment?

There is currently no cure for CFS. The goal of treatment is to reduce or relieve symptoms so you can participate in normal daily activities. Your doctor will recommend that you follow a common-sense regimen of moderate daily exercise, balanced diet, and rest. He or she may also recommend nonsteroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen, to reduce fever and relieve joint and muscle pain. Patients experiencing depression may also benefit from low doses of antidepressants or antianxiety drugs. Drugs that help the body regulate blood pressure and boost the immune system may also be prescribed. Ask your doctor about nutritional supplements that may help boost your immune system and improve your mental functions. Some people also report significant improvements from alternative treatments such as biofeedback, yoga, meditation, and acupuncture.

Self-care tips

There is no known way to prevent CFS because a specific cause has not been found. If you have been diagnosed with CFS, follow your doctor’s treatment recommendations. Try to avoid stressful situations, and seek the help of a therapist if you are troubled by depression and anxiety because of your condition.


This information has been designed as a comprehensive and quick reference guide written by our health care reviewers.  The health information written by our authors is intended to be a supplement to the care provided by your physician.  It is not intended nor implied to be a substitute for professional medical advice. 

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This page was last updated on October 31, 2006
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